Thermo Fisher Scientific Announces a Quick and Simple Method to Simultaneously Quantify Bisphosphonate Pharmaceuticals and Excipients

Top Quote Thermo Fisher Scientific is pleased to announce a fast and easy capillary ion chromatography analytical method to simultaneously quantify bisphosphonate pharmaceuticals and excipients. End Quote
  • San Jose, CA (1888PressRelease) July 24, 2012 - Thermo Fisher Scientific has developed a simple, fast, sensitive, and robust capillary ion chromatography (IC) analytical method to simultaneously quantify three bisphosphonate pharmaceuticals (etidronate, clodronate and tiludronate) and three commonly used excipients (benzoate, hydroxybenzoate and citrate). Application Note 1001: Quantitative Determination of Bisphosphonate Pharmaceuticals and Excipients by Capillary IC-MS uses a Dionex IonPac AS18-Fast capillary anion-exchange column to achieve chromatographic retention and resolution for target analytes. The elimination of derivatization steps simplifies the workflow and improves method throughput. Detection by suppressed conductivity provides sufficient sensitivity for quality control (QC) analysis and mass spectrometry (MS) offers additional selectivity and sensitivity for bisphosphonates in complex matrices, such as biological fluids.

    Bisphosphonates are a group of compounds that are used as active pharmaceutical ingredients (APIs) to treat bone disorders and related conditions, including osteoporosis, Paget's disease, and hypercalcemia.

    This application and many others can be found at under the Documents tab.

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