Small activating RNAs - a novel therapeutic class of oligonucleotides

Top Quote SMi reports: Understanding the principles of RNA activation and possibilities of therapeutic benefit at Oligonucleotide Therapeutics and Delivery Conference 2021. End Quote
  • (1888PressRelease) July 07, 2021 - Engage in the latest innovations of oligonucleotide therapeutics with insights into immunochemotherapeutics, ocular indications and Duchenne Muscular Dystrophy. Deepen your understanding of crucial delivery methods and available platforms for non-hepatocytic delivery.

    Download a copy of your brochure to find out who will be speaking at the upcoming conference in September


    Targeted Delivery of C/EBPa-saRNA by RNA Aptamers

    •Understanding the principles of RNA activation and possibilities of therapeutic benefit
    •Harnessing small activating RNAs for the treatment of Pancreatic ductal adenocarcinoma
    •Evaluating aptamers and appropriate means of targeted delivery
    •Looking at lessons learnt from using saRNA for oncological purposes

    Nagy Habib, Professor of Surgery, Imperial College, Co-founder MiNA therapeutics, Imperial College London

    Small activating RNAs - a novel therapeutic class of oligonucleotides

    •Description of saRNA technology to upregulate transcription and broad applicability to a range of therapeutic targets
    •Generation of a lead candidate saRNA to HNF4a for liver disease
    •Update on MiNA’s lead saRNA clinical agent MTL-CEBPA – Clinical PD and efficacy

    Matthew Catley, Research Director, MiNa Therapeutics Ltd

    The tool-box approach to improve the performance of siRNA-platform technology

    •Interplay of design and function
    •Stability and duration of action
    •Linker design and valency of ligands
    •Is there room for additional improvements?

    Adrien Weingartner, Principal Scientist, Group Leader Drug Delivery, Silence Therapeutics

    Clinical development of AsiDNA, a first in class decoy agonist oligonucleotide targeting DNA damage response in tumor cells

    •Introduction to platON™: proprietary chemistry platform based on a library of decoy agonist oligonucleotides which generates disruptive compounds acting on intracellular DNA-binding targets
    •Introduction to AsiDNA the leading decoy agonist generated from platON and targeting DNA damage response function
    •Recent preclinical highlights: AsiDNA abrogates resistance to multiple anti-cancer targeted therapies
    •Recent clinical development of AsiDNA
    •Outlining next steps of clinical development

    Wael Jdey, Head of Biology, Onxeo S.A.

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    Proudly Sponsored by ChemGenes | Genscript | Tosoh Bioscience

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