Three-dimensional cell cultures as predictive tools in early drug discovery

Top Quote SMi’s Pharma is proud to announce the 3rd Annual 3D Cell Culture is taking place at the Copthorne Tara Hotel in London, UK on 20th and 21st February 2019. End Quote
  • (1888PressRelease) January 09, 2019 - Based on the recent article from *Drug Target Review, three-dimensional cell cultures (spheroids, organoids) are becoming widely used as a new predictive tool in early drug discovery. The use of 3D cell cultures is believed to provide a more physiologically relevant response than monolayer (2D) cell cultures because they closely mimic the extracellular matrix and cell-cell interactions that occur in vivo.

    The drug discovery and development pipeline are retooling imaging technologies, such as high content analysis, to accommodate 3D cell cultures as the model of choice.

    In a high-content assay, subcellular organelles are analysed by high-resolution images captured by automated microscopes. High content imaging and analysis of 3D cell cultures provides:

    • Better predictive information on drug sensitivity
    • Improved drug-target validation
    • More accurate morphological and functional differentiation

    At this year’s 3rd Annual 3D Cell Culture Conference, SMi is delighted to have industry experts share their knowledge and discuss 5 key related sessions to the article above:
    Stefan Pryzborski, Professor of Cell Technology, University of Durham on

    1) Development & application of bioengineering models if human tissues in vitro on
    Novel cell culture technologies are providing new opportunities to bioengineer human tissue constructs in vitro
    Such tissue equivalent models enable the development of new in vitro assays and assessment of drug activity
    Building models that more accurately simulate normal tissue structure for
    R&D use will enhance the predictive accuracy of in vitro assays
    Here we demonstrate the potential of such technology to create new opportunities for discovery research, drug assessment and safety screening
    Sally Price, Head of Cell and Translational Science, Medicines Discovery Catapult on

    2) 3D Cell Culture in the Advancement of Medicines Discovery
    The need for 3D models in developing new medicines and current challenges
    Developments in 3D models that are advancing medicines discovery
    How the Medicines Discovery Catapult is using 3D cell cultures in collaborative projects
    Examples/case studies from our work
    Melanie Matheu, Founder & CEO, Prellis Biologics on

    3) The Future of 3D Cell Culture in Medicine: Blending Medical Devices & Cells to Build Organs
    Organ and tissue design and development
    State of the art for 3D Bioprinting
    Limitations of current systems and methods
    Pathways to full organ replacement
    *William Mattes, Director, Division of Systems Biology, U.S. Food and Drug Administration on

    4) Tools, Not Toys: From Innovation to Regulatory Application
    An incredibly important consideration for any new technology is what decisions will be made by its use
    The “Context of Use” should guide what information is needed to “validate” a new technology
    The role of new technologies in regulatory processes can be informed by Biomarker Drug Development Tool Qualification process developed by FDA and EMA
    *remote presentation
    Michael Raghunath, Head of Center for Cell Biology & Tissue Engineering Director Competence Center TEDD, Zurich University of Applied Sciences on

    5) Amplification of Extracelluar Matrix via Macromolecular Crowding in 2D, 3D, Cell Culture and in Bioprinting
    The importance of the cellular microenvironment in controlling cell behavior and fate
    Current highly aqueous culture conditions impair efficient ECM deposition
    Overcoming this issue by introducing macromolecular crowding (MMC) into the culture medium of monolayer cultures or hydrogels
    MMC adopted by the pharma industry for antifibrotic screening: production of stem cell matrix, and tuning the microarchitecture of bioprinted collagen hydrogels

    If you are interested to learn more about the event or book your place visit

    We have tailored sponsorship packages still available, if you are interested contact Alia Malick, Director, on +44 (0) 20 827 6168 or email amalick ( @ ) smi-online dot co dot uk
    For media enquiries, contact Simi Sapal on +44 (0) 20 7827 6000 or ssapal ( @ ) smi-online dot co dot uk

    3D Cell Culture Conference 2019
    20 – 21 February 2019
    Copthorne Tara Hotel, London, UK
    Follow us ( @ ) SMiPharm


    About SMi Group: Established since 1993, the SMi Group is a global event-production company that specializes in Business-to-Business Conferences, Workshops, Masterclasses and online Communities. We create and deliver events in the Defence, Security, Energy, Utilities, Finance and Pharmaceutical industries. We pride ourselves on having access to the world’s most forward-thinking opinion leaders and visionaries, allowing us to bring our communities together to Learn, Engage, Share and Network. More information can be found at

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