SGS Introduces Innovative Endocrine Disruptor Test for Cosmetic Products
SGS has developed, in combination with NIR Industry, the OEDTest an innovative testing solution to help cosmetic manufacturers verify the absence or presence of estrogenic disruptive activity.
- (1888PressRelease) July 20, 2018 - SGS has introduced an innovative, patented in-vitro analytical technique for detecting and quantifying the activity of estrogenic endocrine disruptors. Developed in combination with NIR Industry, the OEDTest is a major advance for manufacturers who are seeking to develop safe, legally compliant cosmetic products.
Endocrine disruptors are chemicals or natural molecules that have the ability to interfere with the mammalian hormone system and are linked to problems associated with obesity, diabetes, female and male reproduction, hormone-sensitive cancers in females, prostate cancer in males, the thyroid, and the neurodevelopment and neuroendocrine systems. They occur both naturally and as a result of human activity, meaning they can be found in many of the things we use in everyday life. This can result from either their introduction as a raw material, or during production processes, or from interactions between the product and packaging.
Until now cosmetic manufacturers have relied upon laboratory techniques including HPLC, GC, and mass spectrometry which have only focused on the molecules recorded in their screening libraries.
The OEDTest is different because it allows verification of the absence of estrogenic endocrine disruptor activity in the sample. It does this through a two-stage approach to testing. Firstly, the sample is molecular screened for endocrine disruptor activity. If there is evidence of activity, the sample is then taken for precise evaluation, using a cellular test to identify agonist or antagonist effects. The agonist effect will bind the endocrine disruptor to the hormone receptor, making it imitate the effect of a natural hormone (mimetic effect). This will create a signal that will disrupt the endocrine system involved with gene transcription. Conversely, the antagonist effect allows the endocrine disruptor to bind with the hormone receptor without activating it (inhibition effect), thus disrupting gene transcription and creating changes in the regulation of the hormone system.
The results are then evaluated and used by toxicologists when producing the Product Information File (PIF) the absence of estrogenic risk is an additional piece of information that increases the safety aspects of the CMR certificate. All tests comply with directives from the Organization for Economic Co-operation and Development (OECD) (level 2) and relevant cosmetic regulations.
In addition to cosmetic products, the OEDTest can also be used on a wide range of other consumer products, including:
Raw materials: food, pharmaceuticals, plant protection or industrial products
Cleaning or plant protection products
Processed products: ready meals, agri-food
Packaging: container/content interactions
Equipment in contact with the skin and/or bodily fluids
The size of the sample required for the OEDTest depends upon the material being tested:
Raw materials: solid, liquid, powder, viscous, polar, apolar and organic, inorganic or solvent materials to be shipped = min. 10g
Packaging, construction, paint, synthetic, natural or composite materials to be shipped = min. 20g
Finished and packaged manufactured products, to evaluate the container/content interactions as well as the product for consumption to be shipped = whole product in its commercial form
The OEDTest is a simple and effective way for cosmetic manufacturers to ensure that finished products delivered to consumers do not have endocrine-disrupting estrogen-like activity. The test takes a maximum of two weeks from sample delivery to report and, in addition, SGS specialists can offer advice on possible reformulations and/or potential solutions for eliminating the molecules responsible and/or for inhibiting the disruptor function, if the result is positive.
SGS Cosmetics & Personal Care Testing Services
SGS provides testing, inspection, auditing and consulting services to manufacturers, distributors and importers to ensure a high level of product quality in every area. A global network of state of the art laboratories offer custom-made solutions for chemical, biophysical, microbiological, stability and biological aspects. Learn more about SGSs Cosmetics & Personal Care Testing Services. (www.sgs.com/en/consumer-goods-retail/cosmetics-personal-care-and-household/cosmetics-and-personal-care/testing)
To learn more about SGS Cosmetic Product testing and the OEDTest, contact:
Carine Dumas
Sales Engineer for Cosmetics, Personal Care and Household Business
Tel: +33 1 41 24 86 62
Email: crs.media ( @ ) sgs dot com
Website: www.sgs.com/cpch
About SGS
SGS is the worlds leading inspection, verification, testing and certification company. SGS is recognized as the global benchmark for quality and integrity. With more than 95,000 employees, SGS operates a network of over 2,400 offices and laboratories around the world.
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