In recent research at BIOTEC1 a three-step fragment-based screening of PfDHFR was undertaken employing Key Organics BIONET Premium library containing 1163 fragments. This library was chosen over other commercial ones as it is rule-of-three compliant and was curated from any PAINS and aggregating compounds. All fragments are also soluble at 200 mM in DMSO and display high diversity.
The National Center for Genetic Engineering and Biotechnology (BIOTEC) is a research center under the umbrella of the National Science and Technology ...
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