(1888PressRelease)
December 04, 2007 - PhysioStim of France, a specialist in cardiac safety pharmacology, is setting up a new model for isolated cardiomyocytes, which will record all types of ionic currents and action potentials. This model will provide an overview of cardiac physiological mechanisms, drawn up at cellular level.
Testing to detect any possible risk of cardiac toxicity induced by pharmaceuticals is crucial during the preclinical R&D stage. PhysioStim has solid and reliable expertise in this highly specialised area, particularly with hERG assays – potassium channels that are essential in cardiac repolarisation problems. However, in order to obtain a much more comprehensive and integrative approach to cardiac problems, PhysioStim’s experts also offer cardiac action potential recordings, which mimic in vitro the electrophysiological properties that are observable in vivo.
The isolated cells obtained show the proteinic structures and the physiological and biochemical properties preserved, with the advantage of providing a population of cells without neuronal or hormonal influence in a totally controllable environment.
About PhysioStim
PhysioStim, which is headquartered in Lautrec (in southern France), is a contract research organisation (CRO) specialising in cardiac safety pharmacology. It performs for the pharmaceutical and biotechnology industries in vitro electrophysiological studies according to Good Laboratory Practices (GLP), the European (EMEA) and American (FDA) directives and the ICHS7A and S7B guidelines.
For further information, please go to: www.physiostim.com
